Mitophagy is vital in removing damaged mitochondria, maintaining cellular energy metabolism, and reducing oxidative stress
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Moreover, the overexpression of the mitophagy proteins PINK1 and parkin in microglia was demonstrated to significantly inhibit STING-induced inflammation, reduce the levels of insoluble A 142 and A 140 content, and ameliorate the cognitive deficits in the AD mouse model (Fang et al., 2019)
Severe cases with extensive blistering may take two weeks or longer to heal completely