In contrast to PD-L1-mediated T-cell dysfunction induced by glutamine limitation, DON and its prodrug JHU-083 skew CD8(+) T cells toward a highly activated, persistent, and proliferative phenotype, thereby facilitating immunogenic cancer cell death 58,149,150 (Fig
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Interestingly, this article also analysed the correlation between pancreatic tissue GLP-1R expression and DR risk using the SMR approach and found that the correlation remained significant in background DR versus severe non-proliferative DR
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