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While a variable number of Ahx spacers was inserted to minimize steric clash between the NLS and the MDM2-binding interface, the NLS containing stapled peptides showed comparable binding values for MDM2, and were found to have sub-micromolar affinity for importin in a direct fluorescence polarization (FP) assay
Treatment typically involves laxatives
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Dosing protocol frameworks Dose escalation approach: Clinical trials employed gradual dose escalation to manage gastrointestinal tolerability
The ratio of urinary carnitine/acylcarnitine excretion of the patients and healthy controls could have helped us to understand better the altered carnitine-acylcarnitine homeostasis in these late-diagnosed congenital hypothyroid patients under treatment
Children with asthma possessing the GSTP1 val/val genotype had higher malondialdehyde and lower glutathione levels compared with other genotypes in the systemic circulation but not in the airways [33, 62]
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