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RaPID has transformed mRNA display into a powerful tool for identifying potent peptide inhibitors, leading to the establishment of successful companies like PeptiDream

In support of this idea, ablation of GLP1 receptors in the adult (using AAVCre injected directly into the paraventricular hypothalamic nucleus) resulted in marked obesity whereas constitutive deletion of GLP1 receptors in the paraventricular hypothalamic nucleus (using Sim1Cre) failed to alter energy balance (Table 2) (Burmeister et al., 2017

10.1212/WNL.49.6.1621

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Rarely, you might get a headache or feel a little nauseous