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However, unlike 1 mM metformin and 10 nM semaglutide, 10 nM tirzepatide also increased the levels of additional apoptotic biomarkers such as C-Caspase-3, C-Caspase-9, and Bim EL (Figure 1B)

In particular, GIP-R are expressed in macrophages and endothelial cells, and GIP stimulation may improve vascular endothelial function through anti-inflammatory effects and enhancement of NO production 22,34,35,36,37

10.1038/s41580-020-0250-z 30 HoozemansJ

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Single elevated readings may not indicate problems