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SOUL trial: Oral semaglutide demonstrates a 14% reduction in risk of major adverse CV events owenhaskins Oct 24, 2024 2 min read Headline results from the SOUL cardiovascular outcomes trial show the trial achieved its primary objective by demonstrating a statistically significant and superior reduction in major adverse cardiovascular events (MACE) of 14% for people treated with oral semaglutide compared to placebo (based on treatment policy estimand: treatment effect regardless of treatment adherence)

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Changes in the frequency and nature of food intake can shift the existing balance of appetite-regulating substances towards either excessive food craving or sustained reluctance to eat

There have been reports that such compounded versions of the drug have led to high blood pressure, which can lead to heart attacks and strokes