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We understand that linkers influence not only ADC drug release mechanisms and plasma stability but also directly impact clinical efficacy and safety

Fusion between healthy and damaged mitochondria dilutes the damaged mitochondria into the healthy mitochondrial lattice, which in turn maintains overall mitochondrial health (Twig et al., 2008)

ROS: reactive oxygen species

The maleimide released via retro-Michael addition can rapidly covalently bind with plasma albumin, free cysteine, or glutathione, manifested as maleimide exchange (Figure 11a)

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Saturated fats may also activate TLR4s, leading to the stimulation of the inflammatory pathways and cytokine release (34)