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GLP-1R activation reduces blood pressure, as shown in experimental models of hypertension (Hirata et al., 2009

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The intracellular metabolite extracts and 2 mL of spent culture medium containing extracellular metabolites were freeze-dried (BenchTop K manifold freeze dryer, VirTis) prior chemical derivatisation

doi: 10.1111/prd.12096 32 FanX.LiangM.WangL.ChenR.LiH.LiuX

Bruns RF, Daly JW, Snyder SH (1983) Adenosine receptor binding: structure-activity analysis generates extremely potent xanthine antagonists