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The different bas1 mutants showed a significant increase in the production of riboflavin and other growth-related phenotypes (Table 3

28 NAPQI has been shown to modify cysteine residues of the Kelch-like ECH-associated protein 1 (Keap1) protein, activating the Keap1-nuclear factor erythroid 2-related factor 2 (Nrf2) pathway

These findings led to Phase I and II clinical trials of T4 eyedrops (RGN-259) for dry eye and neurotrophic keratopathy, making the ocular surface one of the most clinically advanced use areas for the broader T4/TB-500 compound class

Trial efficacy and safety data do not transfer to an unverified product

It is precisely because of this potency that many of these compounds are experimental, not approved for human use and often banned in sporting competitions