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Gonadotrophin deficiency due to mass effects of pituitary adenomas or gonadotrophin suppression due to cortisol or prolactin excess might induce insulin resistance in men and women that can be improved by hormone replacement therapy

Step 3: Active Testosterone Circulation The freed testosterone then enters circulation, where it binds to sex hormone-binding globulin (SHBG) , albumin, or remains as free testosterone

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Moreover, vitamin C is required for synthesis of norepinephrine (3), and the mineral zinc is important for proper function of GABA, aspartate, and norepinephrine (12)

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