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Leucine supplementation has been shown to have beneficial effects on intestinal health in fish, primarily by improving the morphology of the intestine and increasing intestinal bacterial diversity [78, 107]

In the present study, we found that the activity of Mn-SOD, which is known to be expressed only in the mitochondria, tended to be higher in proline group from 6 to 12 h (P = 0.13 at 6 h, P = 0.19 at 12 h, data not shown)

70 As cells use NADPH to reduce cystine to cysteine, the increased cysteine catabolism by CDO implies the increased consumption of NADPH, which will affect other cell metabolic pathways and the antioxidant capacity as well

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These results provide direct evidence for a role of PDS5B in the protection of stressed replication forks against nucleolytic degradation by the MRN complex