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Yes, significant weight loss from tirzepatide may increase endogenous testosterone production by reducing adipose tissue aromatase activity and improving hypothalamic-pituitary-gonadal axis function

10.1074/jbc.271.46.29415 J

Clinically, B12 shots have long been used to treat cyanide poisoning

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32 Similarly, an association between elevated homocysteine levels and cognitive impairment has been noted, but subsequent vitamin B 12 replacement does not have preventive or therapeutic benefit

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