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Conclusion and perspectives In conclusion, ASD is a complex disease caused by a series of combinations of different aetiological factors, including genetic factors, environmental and immune activation, etc., and ultimately manifests as abnormal changes in molecular signalling pathways, neuronal synapses, immune environment and brain functional connections

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GR catalyzes the reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH), thereby enabling GSH to exert its antioxidant effects and maintain intracellular redox homeostasis [4]