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Further mechanistic studies revealed that calcifediol inhibits the STAT3/AKT/mTOR pathway, suppressing pro-inflammatory cytokine release and keratinocyte hyperproliferation, thereby simultaneously modulating barrier architecture and the immune microenvironment [231]

In some cases, patterns of side effects across multiple subjects may need protocol changes or more safety measures

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In a review of Danish epilepsy patients exposed to phenobarbital for eight to forty-eight years, the primary liver effect was cholestasis, but enzyme induction as reflected by hepatocellular hypertrophy was not obvious (Ward et al

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