GLP-1 evolved to exert rapid transient effects to blunt postprandial glucose excursions, with a plasma half-life of a few minutes 3234 , and is highly susceptible to enzymatic degradation 3537
Maintenance Dose : For most patients, the maintenance dose is the therapeutic dose at which they achieved their desired weight loss or glycemic control (e.g., 1.0 mg or 2.4 mg weekly )
Tirzepatide similarly lasts about 5 days, allowing weekly dosing
Contact your healthcare provider immediately if you experience severe abdominal pain, persistent vomiting, signs of dehydration, or other concerning symptoms
Nat Rev Rheumatol 17 , 475486 (2021)
This is not recommended for amateur research use , IV administration requires sterile conditions and clinical supervision