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Government Rights This product includes CPT which is commercial technical data and/or computer data bases and/or commercial computer software and/or commercial computer software documentation, as applicable which were developed exclusively at private expense by the American Medical Association, 515 North State Street, Chicago, Illinois, 60610

There is no pharmacokinetic interaction requiring dose adjustment, and the compounds can be administered on independent schedules

Evidence Boundary Most studied route in the Phase 2 program, but the OPTIONS trial missed its primary weight-loss endpoint and development was terminated in 2007

Interleukin-1

Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of all heart failure cases, with patients bearing a high symptomatic burden and physical limitations that impact their daily lives

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