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This reduction in inflammation not only prevents further tissue damage but also accelerates the transition from the inflammatory phase to the proliferative phase

TennCare adheres to federal requirements under the Medicaid Drug Rebate Program, ensuring that covered outpatient drugs, including GLP-1 receptor agonists, are available for medically covered indications as defined by TennCare drug coverage policies

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Hence, one potential explanation for the increased efficacy of tirzepatide on glycemic control relative to the monoagonist GLP-1RA is that targeting both incretin receptors maintains some insulinotropic activity even in subjects who are relatively insensitive to GLP-1