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GLP-1 is a target for treatment of diabetes because of the primary peripheral functions of inducing insulin secretion from pancreatic cells, gut emptying and inhibiting glucagon secretion which results in lower blood glucose levels (20)

While it may be argued that our study used relatively small group sizes, the results were significant and reproducible, consistent with the large effect sizes and low variability of our experimental paradigms

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Unfortunately, the study was unable to detect the presence of synapses between the enkephalinergic/ endorphinergic/ dynorphinergic and GHRH neurons because the immunocytochemistry was carried out under light microscope