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Signs you are ready to increase: Appetite suppression has noticeably decreased compared to earlier weeks at this dose Weight loss has stalled for 2+ weeks despite consistent diet and activity Gastrointestinal side effects from the current dose have resolved You have been at the current dose for at least 4 weeks Signs you should stay at your current dose longer: You are still losing weight consistently Appetite suppression remains effective You are experiencing ongoing nausea, vomiting, or fatigue Injection site reactions have not resolved Do not increase just because the schedule says to

Other side effects are very rare

This stability contributes to its practical utility in research settings where consistent dosing matters

Fewer sebaceous glands, lower baseline collagen turnover