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15 A recent population-based cross-sectional gut microbiota analysis has shown that statin therapy is associated with lower gut microbiota dysbiosis, with the predominant difference in the distribution of Bacteroides , Ruminococcaceae , Prevotella , etc

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They also note that only a small number of genetic variants were available for analysis, meaning larger clinical studies are still required before GLP-1 drugs can be recommended for treating depression or bipolar disorder

Without fully characterized impurity standards, immunogenicity risk assessments remain incomplete and vulnerable to regulatory challenge

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