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Research suggests that L-cells are most responsive to nutrients during specific time windows, and that extended fasting periods may enhance L-cell sensitivity

Obes Rev (2022) 23:e13372

Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors a novel mechanism not shared by any currently licensed UK weight management medicine

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Obes Surg

3,4 GLP-1RAs mimic the action of endogenous GLP-1, activating GLP-1R, thereby enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing food intake through central appetite suppression