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As the microenvironment of the failing myocardium during heart failure is mildly acidic 25,26 , the pH-responsive release of TP10 will benefit the application of TP-10@CaP-CTP nanoparticles for heart failure therapy

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For Salviolone, the major potential targeting pathways included Neuroactive ligand-receptor interaction pathway, Calcium signaling pathway, Cholinergic synapse, and Metabolic pathways (Fig

The shelf life after the bottle has been puncture for the first time is 28 days from that date

Add MMP-9 if tracking active tissue remodeling, and TGF-beta if monitoring fibrotic processes

Mieusset R, Bengoudifa B, Bujan L