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However, when combined with insulin or sulphonylureas, the risk increases, and dose adjustments of these concurrent medications may be necessary

This is not a minor technical point

But lowering doses too much may reduce effectiveness, says Pinto, adding there needs to be a steady concentration of GLP-1s in the bloodstream for them to work

(128) in Wistar rats demonstrated that continuous subcutaneous infusion of GLP-1 reversed age-dependent decline in -cell functions

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Effects on Non-Alcoholic Fatty Liver Disease Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress liver injury closely related to IR and genetic variations