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The main mechanisms by which it exerts its effects include: Stimulation of GH: It binds to the growth hormone secretagogue receptor (GHS-R) in the hypothalamus [1] and also acts on the pituitary to promote GH secretion [2]

To date, the spectrum of their biological functions includes gene silencing, DNA damage repair, cell cycle regulation, and cell differentiation (10)

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To facilitate early detection, it is recommended to systematically survey for HF symptoms and signs at each clinical encounter, particularly in individuals with established atherosclerotic cardiovascular disease, hypertension, or chronic kidney disease [94, 95]