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Currently, the association of 0.05% tretinoin with 4% HQ and 0.01% fluocinolone acetonide (triple combination [TC]) is considered the gold-standard topical treatment for melasma owing to its potent and rapid whitening effect [33, 34]

The benefits could be linked to the gene expression of some nuclear factors (poly ADP ribose polymerase-I, NF-B), and peroxisome proliferator-activated receptor together with restored liver function