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The most commonly reported adverse events include: Nausea Vomiting Diarrhea Constipation These are generally dose-dependent and most pronounced during the dose escalation phase

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Onset and dosing Both medications typically start at a low dose that is increased slowly to reduce side effects

HbA1c Targets 48 mmol/mol (6.5%) for individuals not at risk of hypoglycaemia 53 mmol/mol (7.0%) for those on therapies associated with hypoglycaemia Intensification is recommended if HbA1c rises to 58 mmol/mol (7.5%) Targets may be relaxed in older or frail individuals where risks outweigh long-term benefits

Glutathione GOLD consists of a patent-pending, acetylated form of Glutathione