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van Willigenburg H, de Keizer PL, de Bruin RW (April 2018)

A collaborative effort between you and your healthcare provider can lead to the best outcomes

L-arginine supplements are generally not recommended for people who have: kidney disease low blood pressure (hypotension) guanidinoacetate methyltransferase deficiency, an inherited condition that impacts arginine metabolism L-arginine may also interact with medications like those used to treat high blood pressure

Plasma metabolomic markers of insulin resistance and diabetes and rate of incident Parkinsons disease

Those already using metformin or berberine are generally advised in community sources to consider a lower MOTS-c dose with closer monitoring consult a clinician

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