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Janumet XR - Clinical Pharmacology 12.1 Janumet XR Mechanism of Action JANUMET XR JANUMET XR tablets combine two antihyperglycemic agents with complementary mechanisms of action to improve glycemic control in adults with type 2 diabetes mellitus: sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and metformin extended-release, a member of the biguanide class

The extra glucagon activation increases energy expenditure and fat oxidation, which likely accounts for the ~2% higher weight loss in trials

By age 60, approximately 10 to 30 percent of people have reduced acid output

The gradual dose increase helps reduce the potential for gastrointestinal side effects, which are commonly observed with GLP-1 receptor agonists

These medications affect gastric emptying and glucose metabolism , which may pose risks during anaesthesia

The retatrutide FDA timeline hinges on Phase 3 readouts