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Women of childbearing potential must be counseled on avoiding pregnancy while on MB, and if they become pregnant, the drug should be stopped and appropriate medical advice sought

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Persistent emotional flattening, reduced pleasure or a noticeable change in motivation should be discussed with the prescribing clinician particularly if it is affecting relationships, work or everyday life

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PLoS One 9, e100778 Kim MH, Jee JH, Park S, Lee MS, Kim KW, Lee MK (2014) Metformin enhances glucagon-like peptide 1 via cooperation between insulin and Wnt signaling