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Your body requires time to build medication levels in your bloodstream and for your brain's appetite centers to respond to increased GLP-1 signaling

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When dose reduction is appropriate Phase 3 trials include provisions for dose reduction: Gastrointestinal adverse events or inadequate oral intake may warrant stepping down to a lower dose level see Retatrutide Side Effects for incidence rates by dose BMI reaching 22 kg/m or below , or perceived excessive weight loss, allows dose reduction Treatment is discontinued at BMI 18.5 kg/m or below How Often and When to Take Retatrutide Injection frequency once weekly by subcutaneous injection, on the same day each week

This independence allows both compounds to work at full effectiveness simultaneously

GLP-1 receptor agonists work by mimicking a hormone your small intestine naturally produces called glucagon-like peptide-1