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As pointed out above for the catabolism of methionine, the resulting propionyl-CoA is converted, via a mitochondrially-localized, three reaction, ATP-dependent pathway, to succinyl-CoA

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Every production run is subject to rigorous internal controls before it even reaches third-party testing

Accordingly, in 2021 we acquired plasma from one hundred children affected with all three stages of konzo along with their discordant sex-matched siblings and utilized the most up-to-date mass spectrometry analysis to assess potential protein differences