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There is also a novel non-peptide GLP1RA, orforglipron, that causes significant weight loss in overweight and obese patients, but it is not yet FDA-approved [30]

Published online 2013

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A 104-week carcinogenicity study was conducted in male and female Sprague Dawley rats at doses of 0.075, 0.25 and 0.75 mg/kg/day liraglutide administered by bolus subcutaneous injection with exposures 0.5-, 2-and 7-times the exposure in obese humans, respectively, resulting from the MRHD based on plasma AUC comparison

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