Depending on the underlying condition, leg pain may be accompanied by other symptoms, including the following: Cramping or seizing of muscles Tenderness Stiffness Redness or bruising Swelling Muscle weakness or knees buckling Difficulty walking FAQ Causes and Risk Factors of Leg Pain Arthritis Bakers cyst Bone cancer Bone fracture Bursitis Chronic exertional compartment syndrome Claudication Deep vein thrombosis (DVT) Gout Growing pains Hamstring injury Herniated disk in spine LeggCalvPerthes disease Ligament injury Meralgia paresthetica Muscle cramps Muscle strain OsgoodSchlatter disease Osteomyelitis (bone infection) Peripheral artery disease (PAD) Peripheral neuropathy Sacroiliitis Sciatica Shin splints Spinal stenosis Sprains Tendinitis Thrombophlebitis Torn meniscus Varicose veins The following factors are known to increase the risk of developing some common forms of leg pain: Older age Dehydration Pregnancy Diabetes Being overweight or obese Nerve disorders Blood clotting disorders Injury or surgery Prolonged bed rest Sitting for extended periods Smoking Alcohol abuse Athletic activity, especially contact sports How Is Leg Pain Diagnosed

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Two peptides can act on the same cell in two opposite ways without canceling each other out
In particular, GLP-2 increases fasting plasma triglyceride level, very low-density lipoprotein (VLDL) production and hepatic lipogenesis, thereby leading to hepatic steatosis 7
This could include patient-reported symptoms and clinical diagnosis of severe complications
Your healthcare team can help determine whether the cold sensitivity is related to the medication, weight loss, or another underlying condition requiring specific treatment