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Each ApoE4 allele increases AD risk three- to fourfold and lowers the age of onset by approximately 8 years ( ApoE4 also exerts pathological effects by disrupting lipid concentration homeostasis

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The evidence is still preliminary, and more robust trials are needed to confirm the association, says review co-author Pratibha Natesh, an endocrinologist at Warwick Medical School in Coventry, UK

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