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IGF-1 LR3: Receptor Pharmacology and Anabolic Cascade Biology IGF-1 LR3 is a 83-amino acid variant of IGF-1 bearing an N-terminal 13-amino acid Arg extension and a GluArg substitution at position 3, which reduces IGFBP-3 binding affinity by approximately 1000-fold relative to native IGF-1

Conclusion By interrupting the degradation pathways of l-cysteine, serine and GSH and blocking glycogen formation, the GSH production efficiency was significantly improved

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5-fluorouracil enhances the antitumor activity of the glutaminase inhibitor cb-839 against pik3ca-mutant colorectal cancers

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