fsp1 is a glutathione-independent ferroptosis suppressor Identification of structurally diverse inhibitors that sensitize cancer cells to The dual role of FSP1

The species results of these two methods were cross-compared and a result was only considered definitive if it was identified using both methodologies

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As the SOCS box comprises (i) BC box that interacts with elongin B and C and the (ii) Cul box that recruits Cullin 5, these protein complexes can associate with the RING-box protein 2 and other components to form the E3 ubiquitin ligase complex (128130)

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Moreover, DAG extracted from Sargentodoxa cuneate exerts its antioxidant effect by upregulating GPX4 expression and downregulating phosphoextracellular regulated protein kinases and HO-1 expression to counteract APAP-induced ferroptosis in hepatocytes (Liu et al., 2022)