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In clinical practice, GLP-1 receptor agonists are used to manage type 2 diabetes and increasingly for weight-loss or metabolic indications

Muscle loss: Some reports suggest that rapid weight loss from GLP-1s may lead to a decrease in muscle mass

Studies show it can counteract both NO-synthase inhibition (L-NAME) and NO-synthase overstimulation (L-arginine)

Am J Physiol Renal Physiol (2008) 294(2):F41422

If you inject fed, youre sacrificing a significant portion of the lipotropic effect

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