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Patients should be monitored for serious adverse events including pancreatitis (severe abdominal pain radiating to the back, with or without vomiting), gallbladder disease, acute kidney injury (particularly with dehydration from persistent GI symptoms), diabetic retinopathy complications (with Ozempic/Rybelsus), and hypoglycemia (especially when used with insulin or sulfonylureas)
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This is the same mechanism that causes the initial "water weight" when starting creatine but in the context of GLP-1 therapy, maintaining intracellular hydration is a feature, not a bug
GLP-1 medications can be taken off-label by individuals without diabetes to decrease weight
You learn what their role is going to be and what the timing will be with other treatments
