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With an additional change of the CGFS signature to CSYC, reduction of roGFP2 increased only slightly (approximately to 1.8% of class I HsGRX2), but HED activity was increased more efficiently (approximately to 2.5% of class I HsGRX2) 14

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The loss of CNTNAP2 leads to synaptic changes in vitro , reduced inhibitory and axonal excitability defects in acute hippocampal slices (102, 103)