(A from Goldman MP et al: Arch Dermatol 123:1196, 1987.) Figure 7.16 Fibrous cord formation is present 30 days after injection of polidocanol 1.0%
Adherence to mitochondrial proteins, especially in the setting of GSH depletion, is important because mitochondrial protein binding depletes native antioxidant functions and also alters the mitochondrial ATP-synthase -subunit, leading to ineffective ATP production.9,13 Other mechanisms of hepatotoxicity include the formation of toxic free radicals, such as peroxynitrite, from the reaction of superoxide and nitric oxide, subsequently forming nitrotyrosine adducts inside the mitochondria.9,13 GSH repletion not only provides surplus cysteine as an energy substrate for the Krebs cycle, it also serves the important role of scavenging for free radicals and peroxynitrite.9,10 Mitochondria, which are critical for cellular respiration and metabolism, suffer damage to their own mitochondrial DNA by the actions of reactive oxygen species and peroxynitrite compounds, and they have been directly implicated in the process leading to cessation of ATP synthesis.9,11 Many biochemical studies have been performed in murine models
What are the side effects and how can we manage them
Sin embargo, es esencial recordar que los efectos pueden variar segn el contexto y la salud individual
Medicine 91 , 3548 (2012)
Intestinal absorption and tissue distribution of [14C]pyrroloquinoline quinone in mice. Exp
