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Such adverse effects highlight the importance of careful patient selection when prescribing GLP1RA, including identifying those with prior gastrointestinal issues such as severe constipation, prior bowel obstruction or ileus

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J., Nicolau, S., Connolly, A

This leads to neuroinflammation, vascular occlusion, mitochondrial dysfunction, and the aggregation of pathognomonic proteins, which, in turn, trigger neurodegeneration in the cerebral cortex for AD and the substantia nigra for PD (illustrated in Fig