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Currently, AMG-133 is undergoing a phase 2 clinical trial in adults with a BMI of 25 (overweight) or 30 (obese) and obesity-related metabolic disorders, including type 2 diabetes

When administered together, their mechanisms converge to amplify appetite regulation, energy intake reduction, and glycemic improvements, exceeding the individual effects of monotherapy by acting on complementary neuroendocrine circuits regulating body weight and metabolism 1-3

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