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People from South Asian, Chinese, Black African and African-Caribbean backgrounds are at higher risk at lower BMI thresholds

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The practical implication is that a symptom appearing three hours after the needle and one appearing three days later are equally consistent with the drug's behavior and neither can be attributed to the injection itself with confidence

Some published studies have pointed out that while such drugs help patients lose weight, there is a risk of loss of muscle mass

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Third, efforts were made to minimize potential bias due to heterogenous medication adherence in real-world patients, namely (1) the study cohort was restricted to include only stable users of study drugs to eliminate the potential confounding effect from the short-term use or non-adherence of study drugs and (2) sensitivity analyses were performed based on the AT scenario to estimate treatment effectiveness, with patients who discontinued or switched study drugs censored to corroborate our base-case analysis results based on the ITT scenario