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Metformin is commonly used as first-line therapy unless contraindicated or poorly tolerated, but the addition of glucose-lowering therapies with different mechanisms of action is usually needed to provide adequate glycemic control [1,2,3], with the choice of agent being dependent on multiple factors, such as cost and the presence of comorbidities [1]

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PLoS Genet 8: 1-18

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Particularly, the effect of WS on GABA and serotonergic pathways may reduce the activation of the HPA axis, diminishing the secretion of corticotropin-releasing hormone and adrenocorticotropic hormone from the hypothalamus and pituitary, respectively, resulting in lower levels of cortisol released from the adrenal cortex [159]