A systematic review of 63 studies confirmed that elevated GDF-15 is an independent predictor of all-cause and cardiovascular mortality, hospitalization, renal dysfunction, and major adverse cardiac events, mainly in patients with HF and atrial fibrillation (145)
Quantitative Imaging Med
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It has, therefore, been suggested that metabolic stress may influence the pancreatic processing of proglucagon toward the production of GLP-1 as a compensatory response to help regulate glucose homeostasis and maintain -cell function and survival (109, 113)
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thus, analysis of pooled unclassified genera has severe limitations