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Mechanisms of anti-inflammatory and neuroprotective actions of PPAR-gamma agonists

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doi: 10.1677/JOE-09-0132 46 GilmanCPPerryTFurukawaKGriegNHEganJMMattsonMP

Tirzepatide, a dual GIP/GLP-1 receptor agonist, has demonstrated greater efficacy in clinical trials, including the head-to-head SURMOUNT-5 trial comparing it to semaglutide 2.4 mg, potentially producing more substantial weight loss than traditional GLP-1 agonists alone

By influencing metabolic health and blood sugar regulation, they potentially support enhanced energy balance and body composition goals

C., Davies, M