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A little oxidative stress is the trigger for long-term protection

It is important to highlight that elderly persons are at notable risk of the medication overload that elevates the likelihood of APAP exposure 18 , the compromised liver function that facilitates accumulation of toxic metabolites 19 , and the aging-associated disorders, such as Alzheimers disease (AD), that elevate the brains susceptibility to and severity of dyshomeostasis events 20

Gonadorelin is another option

Another possible explanation is that LC works at the hypothalamic level

10.1007/s13361-013-0822-7 [DOI] [PubMed] [Google Scholar] 69.Busso N, Wagtmann N, Herling C, Chobaz-Peclat V, Bischof-Delaloye A, So A, et al