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The vascular damage due to hypertension leads to microinfarcts and white matter lesions, disrupts neuronal connectivity, and creates a harsh environment that induces the spread of A and tau pathologies 65 , 82

Although obesity is generally associated with these comorbidities, some obese individuals seem to be protected as they maintain insulin sensitivity (IS) and show lower hypertension and proatherogenic and inflammatory profiles than their equally obese pathogenic counterparts [29, 30, 31, 32]

In micrograms, that is 5,000mcg/mL

J.MackM.CihakJ.StrutzF.StangassingerM.et al (2001)