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Downregulation of PAI-1 with co-administration of IVT may thus indirectly potentiate plasmin generation and undesired effects of thrombolytic agents, such as BBB disruption 36 , brain edema 36 , and neurotoxicity 37,38

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PAC-1 receptors do not have ligand binding activity until platelet activation and then contributes to platelet thrombus formation

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Women in their teens and 20s are more likely to have symptoms due to excess androgens such as unwanted facial hair and acne