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While they contain the same active ingredient, these medications differ significantly in safety, regulation, cost, and reliability

doi: 10.1016/0014-5793(86)81429-6 31 CalannaSChristensenMHolstJJLaferrreBGluudLLVilsbllTet al

Additionally, metformin reduced HbA1c by 1.5% (16 mmol/mol) and fasting blood glucose by approximately 3.1 mmol/L when titrated to 2000 mg/day for 6 months

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Cold proteins often go down easier during periods of nausea than hot cooked meats

The evidence here is more mixed